Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These changes may contribute to increased cardiovascular disease in the elderly. Inducible antioxidant pathways are regulated by nuclear eryt...

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Bibliographic Details
Main Authors: Sellamuthu S Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J Miller, Kevin J Whitehead, Shannon J Odelberg, Matthew A Firpo, Robert Paine, John R Hoidal, E Dale Abel, Namakkal S Rajasekaran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3454427?pdf=render

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http://europepmc.org/articles/PMC3454427?pdf=render

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