Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy

Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy

Abstract Background Radiotherapy is commonly used for treating cancer. Novel sensitizers, such as gold nanoparticles (GNPs), are being used to enhance the local radiation dose. It is not known how the uptake and radiation dose enhancement of GNPs vary in synchronized vs unsynchronized (control) tumo...

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Bibliographic Details
Main Authors: Kyle Bromma, Kristy Rieck, Jayesh Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter Cullis, Jan Schuemann, Devika B. Chithrani
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Nanotechnology
Subjects:
Gold nanoparticles
Radiation therapy
Synchronization
Monte Carlo simulation
DNA damage
Optical imaging
Online Access:http://link.springer.com/article/10.1186/s12645-019-0046-z

Internet

http://link.springer.com/article/10.1186/s12645-019-0046-z

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