A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein.

Flaviviruses are a group of human pathogenic, enveloped RNA viruses that includes dengue (DENV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses. Cross-reactive antibodies against Flavivirus have been described, but most of them are generally weakly neutralizing. In this...

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Main Authors: Yong-Qiang Deng, Jian-Xin Dai, Guang-Hui Ji, Tao Jiang, Hua-Jing Wang, Hai-ou Yang, Weng-Long Tan, Ran Liu, Man Yu, Bao-Xue Ge, Qing-Yu Zhu, E-De Qin, Ya-Jun Guo, Cheng-Feng Qin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3019176?pdf=render