Progress in LRRK2-Associated Parkinson’s Disease Animal Models

Progress in LRRK2-Associated Parkinson’s Disease Animal Models

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson’s disease (PD). Several genetic manipulations of the LRRK2 gene have been developed in animal models such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish. These models can help...

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Bibliographic Details
Main Authors: Steven P. Seegobin, George R. Heaton, Dongxiao Liang, Insup Choi, Marian Blanca Ramirez, Beisha Tang, Zhenyu Yue
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neuroscience
Subjects:
LRRK2
models
rodent
Drosophila
C. elegans
zebrafish
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00674/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00674/full

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