Cyclic Peptide Extracts Derived From Pseudostellaria heterophylla Ameliorates COPD via Regulation of the TLR4/MyD88 Pathway Proteins

Cyclic Peptide Extracts Derived From Pseudostellaria heterophylla Ameliorates COPD via Regulation of the TLR4/MyD88 Pathway Proteins

We have explored the method of extraction and purification of cyclic-peptide extract (CPE) from Pseudostellaria heterophylla (Miq.) Pax. (Taizishen, TZS), characterized the structure about cyclic-peptide compounds and investigated the biological activity of CPE attenuating chronic obstructive pulmon...

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Bibliographic Details
Main Authors: Feng Lu, Han Yang, Si-ding Lin, Li Zhao, Chang Jiang, Zhi-bin Chen, Ying-ying Liu, Yong-jun Kan, Juan Hu, Wen-sheng Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
Pseudostellaria heterophylla
cyclic peptide
monomer structure
TLR4-MyD88-JNK/p38 pathway
anti-chronic obstructive pulmonary disease
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00850/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00850/full

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