The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection.

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection.

Phagocytic cells capture and kill most invader microbes within the bactericidal phagosome, but some pathogens subvert killing by damaging the compartment and escaping to the cytosol. To prevent the leakage of pathogen virulence and host defence factors, as well as bacteria escape, host cells have to...

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Bibliographic Details
Main Authors: Ana T López-Jiménez, Elena Cardenal-Muñoz, Florence Leuba, Lilli Gerstenmaier, Caroline Barisch, Monica Hagedorn, Jason S King, Thierry Soldati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007501

Internet

https://doi.org/10.1371/journal.ppat.1007501

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