A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?

A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?

GAS (Streptococcus pyogenes) is a leading global cause of infection-related morbidity and mortality. A modern CHIM of GAS pharyngitis could help to accelerate vaccine development and drive pathogenesis research. Challenge strain selection is critical to the safety and success of any CHIM and especia...

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Bibliographic Details
Main Authors: Joshua Osowicki, Kristy I. Azzopardi, Liam McIntyre, Tania Rivera-Hernandez, Cheryl-lynn Y. Ong, Ciara Baker, Christine M. Gillen, Mark J. Walker, Pierre R. Smeesters, Mark R. Davies, Andrew C. Steer
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mSphere
Subjects:
Streptococcus pyogenes
controlled human infection model
group A Streptococcus
human challenge study
pharyngitis
vaccines
Online Access:https://doi.org/10.1128/mSphere.00647-18

Internet

https://doi.org/10.1128/mSphere.00647-18

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