A Controlled Human Infection Model of Group A Streptococcus Pharyngitis: Which Strain and Why?
GAS (Streptococcus pyogenes) is a leading global cause of infection-related morbidity and mortality. A modern CHIM of GAS pharyngitis could help to accelerate vaccine development and drive pathogenesis research. Challenge strain selection is critical to the safety and success of any CHIM and especia...
Main Authors: | Joshua Osowicki, Kristy I. Azzopardi, Liam McIntyre, Tania Rivera-Hernandez, Cheryl-lynn Y. Ong, Ciara Baker, Christine M. Gillen, Mark J. Walker, Pierre R. Smeesters, Mark R. Davies, Andrew C. Steer |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2019-02-01
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Series: | mSphere |
Subjects: | |
Online Access: | https://doi.org/10.1128/mSphere.00647-18 |
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