Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine kinase DYRK1A, as a candidate for inducing cognit...

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Bibliographic Details
Main Authors: Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
DYRK1A
Excitation
Inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001053

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http://www.sciencedirect.com/science/article/pii/S0969996114001053

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