Comparison of the Inhibitory Binding Modes Between the Planar Fascaplysin and Its Nonplanar Tetrahydro-β-carboline Analogs in CDK4

Comparison of the Inhibitory Binding Modes Between the Planar Fascaplysin and Its Nonplanar Tetrahydro-β-carboline Analogs in CDK4

Fascaplysin is a natural marine product originating from sponges, attracting widespread attention due to its potential inhibitory activities against CDK4. However, its clinical application has been largely limited because of serious adverse effects caused by planar skeleton. To reduce the serious ad...

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Bibliographic Details
Main Authors: Yan Liang, Huili Quan, Tong Bu, Xuedong Li, Xingang Liu, Songsong Wang, Dian He, Qingzhong Jia, Yang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Chemistry
Subjects:
fascaplysin
nonplanar
MTT assay
molecular docking
MD simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.614154/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.614154/full

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