The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

Abstract The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Based on these findings, the recent cloning of the Sigma-2 receptor (σ2R) led us to...

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Bibliographic Details
Main Authors: Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos, Javier Garzón-Niño
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Brain
Subjects:
Sigma 2 receptor
Sigma 1 receptor
Knockout mice
Mu opioid receptor
Neuropathic pain
Analgesia
Online Access:http://link.springer.com/article/10.1186/s13041-020-00676-4

Internet

http://link.springer.com/article/10.1186/s13041-020-00676-4

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