Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility

Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility

Cutaneous melanoma is an aggressive tumor with its incidence increasing faster than any other cancer in the past decades. Melanoma is a heterogeneous tumor, with most patients harboring mutations in the BRAF or NRAS oncogenes, leading to the overactivation of the MAPK/ERK and PI3K/Akt pathways. The...

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Bibliographic Details
Main Authors: Monica Marzagalli, Marina Montagnani Marelli, Lavinia Casati, Fabrizio Fontana, Roberta Manuela Moretti, Patrizia Limonta
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Endocrinology
Subjects:
Melanoma
Phytoestrogens
targeted therapy
BRAF
NRAS
ERβ
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00140/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00140/full

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