Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
Polo-like kinases (Plks) are a family of serine-threonine kinases that regulate multiple intracellular processes including DNA replication, mitosis, and stress response. Plk1, the most well understood family member, regulates numerous stages of mitosis and is overexpressed in many cancers. Plk inhib...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523315000261 |