Challenges of inversely estimating Jacobian from metabolomics data

Inferring dynamics of metabolic networks directly from metabolomics data provides a promising way to elucidate the underlying mechanisms of biological systems, as reported in our previous studies [1-3] by a differential Jacobian approach. The Jacobian is solved from an over-determined system of equa...

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Bibliographic Details
Main Authors: Xiaoliang eSun, Bettina eLänger, Wolfram eWeckwerth
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00188/full