Genomic instability in a chronic lymphocytic leukemia patient with mono-allelic deletion of the DLEU and RB1 genes

Genomic instability in a chronic lymphocytic leukemia patient with mono-allelic deletion of the DLEU and RB1 genes

Abstract Background The most frequent cytogenetic abnormality detected in chronic lymphocytic leukemia (CLL) patients is the presence of a deletion within the chromosome band 13q14. Deletions can be heterogeneous in size, generally encompassing the DLEU1 and DLEU2 genes (minimal deleted region), but...

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Bibliographic Details
Main Authors: María Paulina Nava-Rodríguez, Martín Daniel Domínguez-Cruz, Lilia Beatriz Aguilar-López, César Borjas-Gutiérrez, María Teresa Magaña-Torres, Juan Ramón González-García
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Cytogenetics
Subjects:
Chronic lymphocytic leukemia
13q14 deletion, DLEU and RB1 gene loss
Genomic instability
Online Access:http://link.springer.com/article/10.1186/s13039-019-0417-5

Internet

http://link.springer.com/article/10.1186/s13039-019-0417-5

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