Human Transbodies to Reverse Transcriptase Connection Subdomain of HIV-1 Gag-Pol Polyprotein Reduce Infectiousness of the Virus Progeny

Human Transbodies to Reverse Transcriptase Connection Subdomain of HIV-1 Gag-Pol Polyprotein Reduce Infectiousness of the Virus Progeny

HIV-1 progeny are released from infected cells as immature particles that are unable to infect new cells. Gag-Pol polyprotein dimerization via the reverse transcriptase connection domain (RTCDs) is pivotal for proper activation of the virus protease (PR protein) in an early event of the progeny viru...

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Bibliographic Details
Main Authors: Watee Seesuay, Siratcha Phanthong, Jaslan Densumite, Kodchakorn Mahasongkram, Nitat Sookrung, Wanpen Chaicumpa
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
human single-chain antibodies (HuscFvs)
cell-penetrating antibodies (transbodies)
human immunodeficiency virus 1 (HIV-1)
reverse transcriptase connection subdomain (RTCD)
Gag-Pol polyprotein
Online Access:https://www.mdpi.com/2076-393X/9/8/893

Internet

https://www.mdpi.com/2076-393X/9/8/893

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