The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy

Abstract Background PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding to its receptor PD-1, which works in braking inflammatory response and conspiring tumor immune evasion. However, in gliomas, the cause of PD-L1 expression in the tumor microenv...

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Bibliographic Details
Main Authors: Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua Liu, Yiwei Chu
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
PD-L1
Immune checkpoint
IFN-γ
Glioma
Immune evasion
Online Access:http://link.springer.com/article/10.1186/s12974-018-1330-2

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http://link.springer.com/article/10.1186/s12974-018-1330-2

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