Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy in vivo

Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy in vivo

Diabetic peripheral neuropathic pain (DPNP) is the most devastating complication of diabetes mellitus. Unfortunately, successful therapy for DPNP remains a challenge because its pathogenesis is still elusive. However, DPNP is believed to be due partly to abnormal hyperexcitability of dorsal root gan...

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Bibliographic Details
Main Authors: Laiche Djouhri, Asad Zeidan, Seham A. Abd El-Aleem, Trevor Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
action potential
diabetic neuropathy
nociception
primary sensory neurons
K+ channels
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00530/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00530/full

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