Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation

Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation

Protein aggregates in affected motor neurons are a hallmark of amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to their formation remain incompletely understood. Oxidative stress associated with age, the major risk factor in ALS, contributes to this neurodegeneration in ALS....

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Bibliographic Details
Main Authors: Audrey Dangoumau, Sylviane Marouillat, Roxane Coelho, François Wurmser, Céline Brulard, Shanez Haouari, Frédéric Laumonnier, Philippe Corcia, Christian R. Andres, Hélène Blasco, Patrick Vourc'h
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
ALS
ubiquitin
SUMO
SOD1
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/22/4/1796

Internet

https://www.mdpi.com/1422-0067/22/4/1796

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