The role of SIRT1 in diabetic kidney disease
Sirtuins (SIRTs) are members of the silent information regulator 2 (Sir2) family. In mammals, of the seven known SIRTs, SIRT1 function is most studied and has been shown to regulate wide range of cellular functions that affect metabolic homeostasis and aging. SIRT1 exerts anti-apoptotic, anti-oxidat...
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doaj-391712f149f74497bd5f526ac08acd5d2020-11-24T23:24:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-10-01510.3389/fendo.2014.00166117069The role of SIRT1 in diabetic kidney diseaseRabi eYacoub0Kyung eLee1John Cijiang He2Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount SinaiSirtuins (SIRTs) are members of the silent information regulator 2 (Sir2) family. In mammals, of the seven known SIRTs, SIRT1 function is most studied and has been shown to regulate wide range of cellular functions that affect metabolic homeostasis and aging. SIRT1 exerts anti-apoptotic, anti-oxidative, and anti-inflammatory effects against cellular injury, and protects the cells through the regulation of mitochondrial biogenesis, autophagy, and metabolism in response to the cellular energy and redox status. SIRT1 also promotes vasodilation and protects vascular tissues. In humans and animal models with diabetic kidney disease, its expression tends to be decreased in renal cells, and increased expression of SIRT1 was found to play a renal protective role in animal models with diabetic kidney disease. In this review we discuss the role and potential mechanisms by which SIRT1 protects against DKD.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00166/fullApoptosisAutophagyDiabetes MellitussenescenceSIRT1SIRTUIN |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rabi eYacoub Kyung eLee John Cijiang He |
spellingShingle |
Rabi eYacoub Kyung eLee John Cijiang He The role of SIRT1 in diabetic kidney disease Frontiers in Endocrinology Apoptosis Autophagy Diabetes Mellitus senescence SIRT1 SIRTUIN |
author_facet |
Rabi eYacoub Kyung eLee John Cijiang He |
author_sort |
Rabi eYacoub |
title |
The role of SIRT1 in diabetic kidney disease |
title_short |
The role of SIRT1 in diabetic kidney disease |
title_full |
The role of SIRT1 in diabetic kidney disease |
title_fullStr |
The role of SIRT1 in diabetic kidney disease |
title_full_unstemmed |
The role of SIRT1 in diabetic kidney disease |
title_sort |
role of sirt1 in diabetic kidney disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2014-10-01 |
description |
Sirtuins (SIRTs) are members of the silent information regulator 2 (Sir2) family. In mammals, of the seven known SIRTs, SIRT1 function is most studied and has been shown to regulate wide range of cellular functions that affect metabolic homeostasis and aging. SIRT1 exerts anti-apoptotic, anti-oxidative, and anti-inflammatory effects against cellular injury, and protects the cells through the regulation of mitochondrial biogenesis, autophagy, and metabolism in response to the cellular energy and redox status. SIRT1 also promotes vasodilation and protects vascular tissues. In humans and animal models with diabetic kidney disease, its expression tends to be decreased in renal cells, and increased expression of SIRT1 was found to play a renal protective role in animal models with diabetic kidney disease. In this review we discuss the role and potential mechanisms by which SIRT1 protects against DKD. |
topic |
Apoptosis Autophagy Diabetes Mellitus senescence SIRT1 SIRTUIN |
url |
http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00166/full |
work_keys_str_mv |
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