Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10

Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10

Bone marrow plasma cells have been reported to represent a major source of IL-10; however, the impact of plasma cell derived IL-10 in that tissue remains poorly understood. We confirm in this study that even in the absence of acute immune reactions, mature plasma cells represent the dominant IL-10+...

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Bibliographic Details
Main Authors: Lingzhang Meng, Larissa Nogueira Almeida, Ann-Katrin Clauder, Timo Lindemann, Julia Luther, Christopher Link, Katharina Hofmann, Upasana Kulkarni, David Ming Wong, Jean-Pierre David, Rudolf Armin Manz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
B cells
plasma cells
IL-10
monocytes
aging
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01183/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01183/full

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