The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs

The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs

Summary: The specification of the hepatic identity during human liver development is strictly controlled by extrinsic signals, yet it is still not clear how cells respond to these exogenous signals by activating secretory cascades, which are extremely relevant, especially in 3D self-organizing syste...

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Bibliographic Details
Main Authors: Federica Michielin, Giovanni G. Giobbe, Camilla Luni, Qianjiang Hu, Ida Maroni, Michael R. Orford, Anna Manfredi, Lucio Di Filippo, Anna L. David, Davide Cacchiarelli, Paolo De Coppi, Simon Eaton, Nicola Elvassore
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
microfluidics
SILAC-MS
proteome analysis
ECM remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031442X

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http://www.sciencedirect.com/science/article/pii/S221112472031442X

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