Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells.

Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells.

Local skin flaps often present with flap necrosis caused by critical disruption of the blood supply. Although animal studies demonstrate enhanced angiogenesis in ischemic tissue, no strategy for clinical application of this phenomenon has yet been defined. Hypoxia-inducible factor 1 (HIF-1) plays a...

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Bibliographic Details
Main Authors: Mitsuru Takaku, Shuhei Tomita, Hirotsugu Kurobe, Yoshitaka Kihira, Atsushi Morimoto, Mayuko Higashida, Yasumasa Ikeda, Akira Ushiyama, Ichiro Hashimoto, Hideki Nakanishi, Toshiaki Tamaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3413653?pdf=render

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http://europepmc.org/articles/PMC3413653?pdf=render

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