Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.

Bibliographic Details
Main Authors: Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24215-4

Internet

https://doi.org/10.1038/s41467-021-24215-4

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