Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.

Bibliographic Details
Main Authors: Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24215-4
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spelling doaj-391d00d31af043e1bbe47abd090874512021-06-27T11:11:27ZengNature Publishing GroupNature Communications2041-17232021-06-0112111610.1038/s41467-021-24215-4Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagyDavy Vanhoutte0Tobias G. Schips1Alexander Vo2Kelly M. Grimes3Tanya A. Baldwin4Matthew J. Brody5Federica Accornero6Michelle A. Sargent7Jeffery D. Molkentin8Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical CenterBeneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.https://doi.org/10.1038/s41467-021-24215-4
collection DOAJ
language English
format Article
sources DOAJ
author Davy Vanhoutte
Tobias G. Schips
Alexander Vo
Kelly M. Grimes
Tanya A. Baldwin
Matthew J. Brody
Federica Accornero
Michelle A. Sargent
Jeffery D. Molkentin
spellingShingle Davy Vanhoutte
Tobias G. Schips
Alexander Vo
Kelly M. Grimes
Tanya A. Baldwin
Matthew J. Brody
Federica Accornero
Michelle A. Sargent
Jeffery D. Molkentin
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
Nature Communications
author_facet Davy Vanhoutte
Tobias G. Schips
Alexander Vo
Kelly M. Grimes
Tanya A. Baldwin
Matthew J. Brody
Federica Accornero
Michelle A. Sargent
Jeffery D. Molkentin
author_sort Davy Vanhoutte
title Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_short Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_full Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_fullStr Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_full_unstemmed Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_sort thbs1 induces lethal cardiac atrophy through perk-atf4 regulated autophagy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.
url https://doi.org/10.1038/s41467-021-24215-4
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