Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1G93A Amyotrophic Lateral Sclerosis

Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1G93A Amyotrophic Lateral Sclerosis

The rate of disease progression in amyotrophic lateral sclerosis (ALS) is highly variable, even between patients with the same genetic mutations. Metabolic alterations may affect disease course variability in ALS patients, but challenges in identifying the preclinical and early phases of the disease...

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Bibliographic Details
Main Authors: Gabriel N. Valbuena, Lavinia Cantoni, Massimo Tortarolo, Caterina Bendotti, Hector C. Keun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
SOD1G93A ALS mouse model
metabolism
metabolomics
spinal cord
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01276/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01276/full

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