A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, is considered to be a new therapeutic target for Parkinson’s disease (PD). However, only several small-molecule TFEB activators have been discovered and their neuroprotective effects in PD are...

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Bibliographic Details
Main Authors: Ziying Wang, Chuanbin Yang, Jia Liu, Benjamin Chun-Kit Tong, Zhou Zhu, Sandeep Malampati, Sravan Gopalkrishnashetty Sreenivasmurthy, King-Ho Cheung, Ashok Iyaswamy, Chengfu Su, Jiahong Lu, Juxian Song, Min Li
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
tfeb
parkinson’s disease
α-synuclein
curcumin derivatives
mtorc1
Online Access:https://www.mdpi.com/1422-0067/21/4/1515

Internet

https://www.mdpi.com/1422-0067/21/4/1515

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