Favipiravir (T-705) Protects IFNAR<sup>−/−</sup> Mice against Lethal Zika Virus Infection in a Sex-Dependent Manner

Favipiravir (T-705) Protects IFNAR<sup>−/−</sup> Mice against Lethal Zika Virus Infection in a Sex-Dependent Manner

Zika virus (ZIKV), a member of the <i>Flaviviridae</i> family, is an important human pathogen that has caused epidemics in Africa, Southeast Asia, and the Americas. No licensed treatments for ZIKV disease are currently available. Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxami...

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Bibliographic Details
Main Authors: Keesha Matz, Jackson Emanuel, Julie Callison, Don Gardner, Rebecca Rosenke, Reinaldo Mercado-Hernandez, Brandi N. Williamson, Heinz Feldmann, Andrea Marzi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
flavivirus
ZIKV
mouse model
sex bias
ribavirin
antiviral
Online Access:https://www.mdpi.com/2076-2607/9/6/1178

Internet

https://www.mdpi.com/2076-2607/9/6/1178

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