Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice

Platelet collagen interactions at sites of vascular injuries predominantly involve glycoprotein VI (GPVI) and the integrin α2β1. Both proteins are primarily expressed on platelets and megakaryocytes whereas GPVI expression is also shown on endothelial and integrin α2&#...

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Bibliographic Details
Main Authors: Michael K. Schuhmann, Peter Kraft, Michael Bieber, Alexander M. Kollikowski, Harald Schulze, Bernhard Nieswandt, Mirko Pham, David Stegner, Guido Stoll
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
ischemic stroke
integrin α2
glycoprotein VI
recombinant tissue-type plasminogen activator
intracranial bleeding
transient middle cerebral artery occlusion
Online Access:https://www.mdpi.com/1422-0067/20/8/2019

Internet

https://www.mdpi.com/1422-0067/20/8/2019

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