Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle

Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle

Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3). INSL3 displays anabolic activity on bone, a target tissue of androgens,...

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Bibliographic Details
Main Authors: Alberto Ferlin, Luca De Toni, Alexander I. Agoulnik, Giorgia Lunardon, Andrea Armani, Sergia Bortolanza, Bert Blaauw, Marco Sandri, Carlo Foresta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
INSL3
Leydig cells
hypogonadism
leg denervation
protein synthesis
ubiquitin-proteasome system
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00562/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00562/full

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