Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicr...
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Bibliographic Details
| Main Authors: |
Hao Yu,
Patricia Dranchak,
Zhiru Li,
Ryan MacArthur,
Matthew S. Munson,
Nurjahan Mehzabeen,
Nathan J. Baird,
Kevin P. Battalie,
David Ross,
Scott Lovell,
Clotilde K. S. Carlow,
Hiroaki Suga,
James Inglese |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14932
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