Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments

Summary: T cells compete with malignant cells for limited nutrients within the solid tumor microenvironment. We found that effector memory CD4 T cells respond distinctly from other T cell subsets to limiting glucose and can maintain high levels of interferon-γ (IFN-γ) production in a nutrient-poor e...

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Bibliographic Details
Main Authors: Christopher Ecker, Lili Guo, Stefana Voicu, Luis Gil-de-Gómez, Andrew Medvec, Luis Cortina, Jackie Pajda, Melanie Andolina, Maria Torres-Castillo, Jennifer L. Donato, Sarya Mansour, Evan R. Zynda, Pei-Yi Lin, Angel Varela-Rohena, Ian A. Blair, James L. Riley
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718304455

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http://www.sciencedirect.com/science/article/pii/S2211124718304455

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