T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between species has not been characterized. Using network analysis of high-throughput TCR sequencing...

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Bibliographic Details
Main Authors: Asaf Madi, Asaf Poran, Eric Shifrut, Shlomit Reich-Zeliger, Erez Greenstein, Irena Zaretsky, Tomer Arnon, Francois Van Laethem, Alfred Singer, Jinghua Lu, Peter D Sun, Irun R Cohen, Nir Friedman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
lymphocyte subsets
T cell receptor
CDR3
Online Access:https://elifesciences.org/articles/22057

Internet

https://elifesciences.org/articles/22057

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