Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

Dengue virus (DENV) is the most significant human arboviral pathogen and causes ∼400 million infections in humans each year. In previous work, we observed that mast cells (MC) mediate vascular leakage during DENV infection in mice and that levels of MC activation are correlated with disease severity...

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Bibliographic Details
Main Authors: Ayesa Syenina, Cyril J Jagaraj, Siti AB Aman, Aishwarya Sridharan, Ashley L St John
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
dengue virus
vascular leakage
antibodies
mast cell
Fc receptor
Online Access:https://elifesciences.org/articles/05291

Internet

https://elifesciences.org/articles/05291

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