T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity...

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Bibliographic Details
Main Authors: Lisa Perruzza, Giorgio Gargari, Michele Proietti, Bruno Fosso, Anna Maria D’Erchia, Caterina Elisa Faliti, Tanja Rezzonico-Jost, Daniela Scribano, Laura Mauri, Diego Colombo, Giovanni Pellegrini, Annalisa Moregola, Catherine Mooser, Graziano Pesole, Mauro Nicoletti, Giuseppe Danilo Norata, Markus B. Geuking, Kathy D. McCoy, Simone Guglielmetti, Fabio Grassi
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
T follicular helper cells
IgA
P2rx7
ATP
microbiota
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302760

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http://www.sciencedirect.com/science/article/pii/S2211124717302760

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