TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts

TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts

The correct organization of mitochondrial DNA (mtDNA) in nucleoids and the contacts of mitochondria with the ER play an important role in maintaining the mitochondrial genome distribution within the cell. Mitochondria-associated ER membranes (MAMs) consist of interacting proteins and lipids located...

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Bibliographic Details
Main Authors: Koit Aasumets, Yuliya Basikhina, Jaakko L. Pohjoismäki, Steffi Goffart, Joachim Gerhold
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Mitochondrial DNA
Nucleoids
Mitochondrial transcription factor A (TFAM)
Organellar membranes
TWNK helicase
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002363

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http://www.sciencedirect.com/science/article/pii/S2405580821002363

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