PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

Summary: Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked to poor response to chemotherapy. Various PRMT1 inhibitors are currently under development; yet, we do not fully understand the mechanisms underpinning PRMT1 involvement in tumorigenesis and ch...

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Bibliographic Details
Main Authors: Daniele Musiani, Roberto Giambruno, Enrico Massignani, Marica Rosaria Ippolito, Marianna Maniaci, Sriganesh Jammula, Daria Manganaro, Alessandro Cuomo, Luciano Nicosia, Diego Pasini, Tiziana Bonaldi
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719317188

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http://www.sciencedirect.com/science/article/pii/S2211124719317188

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