Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

The goal of this research was to prepare and characterize nanonized particles of the antifungal drug, fluconazole (FLZ) using antisolvent precipitation nanonization technique to improve its ocular permeation. The impact of various concentrations of different stabilizers, namely Pluronic F-127 (PL F...

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Bibliographic Details
Main Authors: Amal El Sayeh F. Abou El Ela, Mohamed Abbas Ibrahim, Yara Alqahtani, Aliyah Almomen, Fadilah Sfouq Aleanizy
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Saudi Pharmaceutical Journal
Subjects:
Nanonization
Antisolvent precipitation nanonization
Stabilizers
Fluconazole
Ocular delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S131901642100075X

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http://www.sciencedirect.com/science/article/pii/S131901642100075X

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