Amiloride is neuroprotective in an MPTP model of Parkinson's disease

Amiloride is neuroprotective in an MPTP model of Parkinson's disease

The diuretic amiloride has recently proven neuroprotective in models of cerebral ischemia, a property attributable to the drug's inhibition of central acid-sensing ion channels (ASICs). Given that Parkinson's disease (PD), like ischemia, is associated with cerebral lactic acidosis, we test...

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Bibliographic Details
Main Authors: Robert L. Arias, Mei-Li A. Sung, Dmytro Vasylyev, Mei-Yi Zhang, Kristin Albinson, Katie Kubek, Natasha Kagan, Chad Beyer, Qian Lin, Jason M. Dwyer, Margaret M. Zaleska, Mark R. Bowlby, John Dunlop, Michael Monaghan
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Neurobiology of Disease
Subjects:
MPTP
Amiloride
Psalmotoxin
Substantia nigra
Parkinson's disease
Dopamine transporter
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001010

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http://www.sciencedirect.com/science/article/pii/S0969996108001010

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