Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer.
Genome-wide association studies typically target inherited autosomal variants, but less studied genetic mechanisms can play a role in complex disease. Sex-linked variants aside, three genetic phenomena can induce differential risk in maternal versus paternal lineages of affected individuals: 1. mate...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-03-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3961172?pdf=render |