Histone deacetylase inhibitors – molecular mechanisms of actions and clinical applications

Histone deacetylase inhibitors – molecular mechanisms of actions and clinical applications

Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene expression implicated in cancer pathogenesis. Inhibitors of HDACs (HDI) are under investigation as novel anti-cancer drugs, which induce histone hyperacetylation. These agents modulate chromatin structure leadin...

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Bibliographic Details
Main Authors:	Aneta Grabarska, Magdalena Dmoszyńska-Graniczka, Ewa Nowosadzka, Andrzej Stepulak
Format:	Article
Language:	English
Published:	Index Copernicus International S.A. 2013-08-01
Series:	Postępy Higieny i Medycyny Doświadczalnej
Subjects:	Clinical Trials angiogenesis Apoptosis Cell Cycle Histone Deacetylase Inhibitors
Online Access:	http://journals.indexcopernicus.com/fulltxt.php?ICID=1061381

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