Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα.

Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα.

Dysfunction of histone acetylation inhibits topoisomerase IIα (Topo IIα), which is implicated in benzene-induced hematotoxicity in patients with chronic benzene exposure. Whether histone deacetylase (HDAC) inhibitors can relieve benzene-induced hematotoxicity remains unclear. Here we showed that hyd...

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Bibliographic Details
Main Authors: Jingjing Chen, Zhouyi Zheng, Yi Chen, Jiaqi Li, Shanhu Qian, Yifen Shi, Lan Sun, Yixiang Han, Shenghui Zhang, Kang Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4826000?pdf=render

Internet

http://europepmc.org/articles/PMC4826000?pdf=render

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