Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida albicans by Competitively Inhibiting Efflux Pump

Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida albicans by Competitively Inhibiting Efflux Pump

The frequent emergence of azole-resistant strains has increasingly led azoles to fail in treating candidiasis. Combination with other drugs is a good option to effectively reduce or retard its incidence of resistance. Natural products are a promising synergist source to assist azoles in treating res...

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Bibliographic Details
Main Authors: Jiali Xu, Ruihuan Liu, Fujuan Sun, Lin An, Zhichun Shang, Lingyi Kong, Minghua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
fluconazole resistance
Candida albicans
eucalyptal D
efflux pump substrate
synergism
formyl-phloroglucinol meroterpenoids
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00211/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00211/full

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