Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15α-hydroxylithocholic acid

Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15α-hydroxylithocholic acid

The major bile acids present in the gallbladder bile of the common Australian wombat (Vombatus ursinus) were isolated by preparative HPLC and identified by NMR as the taurine N-acylamidates of chenodeoxycholic acid (CDCA) and 15α-hydroxylithocholic acid (3α,15α-dihydroxy-5β-cholan-24-oic acid). Taur...

Full description

Bibliographic Details
Main Authors: Genta Kakiyama, Hideyuki Tamegai, Takashi Iida, Kuniko Mitamura, Shigeo Ikegawa, Takaaki Goto, Nariyasu Mano, Junichi Goto, Peter Holz, Lee R. Hagey, Alan F. Hofmann
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Journal of Lipid Research
Subjects:
bile acid synthesis
detoxification of bile acids
bile acid metabolism in marsupials
15-hydroxylation
lithocholic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520429190

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520429190

Similar Items