Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Abstract Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated protein kina...

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Bibliographic Details
Main Authors: Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebastián Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcón, B. Daan Westenbrink, Sergio Lavandero, Manuel Estrada
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Biological Research
Subjects:
Testosterone
AMP-activated protein kinase
Glucose transport
Glycolysis
Androgen receptor
Cardiac hypertrophy
Online Access:https://doi.org/10.1186/s40659-021-00328-4

Internet

https://doi.org/10.1186/s40659-021-00328-4

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