HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial–mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation

HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial–mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation

HYD-PEP06, an endostatin-modified polypeptide, has been shown to produce effective anti-colorectal carcinoma effects through inhibiting epithelial–mesenchymal transition (EMT). However, whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma (HCC) remained unknown. In this study...

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Bibliographic Details
Main Authors: Wei Tian, Jiatong Li, Zhuo Wang, Tong Zhang, Ying Han, Yanyan Liu, Wenfeng Chu, Yu Liu, Baofeng Yang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Hepatocellular carcinoma
HYD-PEP06
Cancer stem-like cell
PI3K/AKT
WNT/β-catenin
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100112X

Internet

http://www.sciencedirect.com/science/article/pii/S221138352100112X

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