Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved. We demonstrate here that ATM-deficient cells are exquisitely sensitive to nutrient deprivation, which can be explai...

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Bibliographic Details
Main Authors: Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Cell Biology
Organizational Aspects of Cell Biology
Functional Aspects of Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422031169X

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http://www.sciencedirect.com/science/article/pii/S258900422031169X

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