Binding of Fidarestat Stereoisomers with Aldose Reductase

Binding of Fidarestat Stereoisomers with Aldose Reductase

The stereospecificity in binding to aldose reductase (ALR2) of two fidarestat {6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide} stereoisomers [(2S,4S)and (2R,4S)] has been investigated by means of molecular dynamics simulations using freeenergy integration techniqu...

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Bibliographic Details
Main Authors: Dae-Sil Lee, Suk-In Hong, Dooil Kim
Format: Article
Language:English
Published: MDPI AG 2006-11-01
Series:International Journal of Molecular Sciences
Subjects:
Aldose reductase
Fidarestat
Stereospecificity
Molecular dynamics
Free energy.
Online Access:http://www.mdpi.com/1422-0067/7/11/519/

Internet

http://www.mdpi.com/1422-0067/7/11/519/

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