Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.

Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors.

During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that recruit phagocytes to foci of infection. The ephrin type-A receptor 2 (EphA2) detects β-glucan and plays a central role in stimulating epithel...

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Bibliographic Details
Main Authors: Marc Swidergall, Norma V Solis, Nicolas Millet, Manning Y Huang, Jianfeng Lin, Quynh T Phan, Michael D Lazarus, Zeping Wang, Michael R Yeaman, Aaron P Mitchell, Scott G Filler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009221

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https://doi.org/10.1371/journal.ppat.1009221

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