HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis

HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis

In multiple sclerosis (MS), post-mortem studies of human brain tissue as well as data from animal models have shown that apoptosis of neurons occurs to a significant extent during this disease. As neurodegeneration in MS correlates with permanent neurological deficits in patients, understanding the...

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Bibliographic Details
Main Authors: Ricarda Diem, Naimeh Taheri, Gunnar P.H. Dietz, Antje Kuhnert, Katharina Maier, Muriel B. Sättler, Ivana Gadjanski, Doron Merkler, Mathias Bähr
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Tat-Bcl-XL
Bcl-2 family
Experimental autoimmune encephalomyelitis
Neuroprotection
Retinal ganglion cells
Visual evoked potentials
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000744

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http://www.sciencedirect.com/science/article/pii/S0969996105000744

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